Pioneering producer of biodegradable fiber format for drug delivery, TissueGen® Inc., announced that it will be present during the upcoming annual Society for Neuroscience meeting (Neuroscience 2014). A team of researchers, whose latest work made use of TissueGen’s proprietary ELUTE® Biodegradable Drug-loaded (BDL) fibers and chemical gradient technology to induce nerve regeneration in paralytic patients, have been invited to present a poster of their novel method and findings. They will be represented by Dr. Nesreen Alsmadi, a post-doctorate fellow at the UT Dallas Laboratory of Regenerative Neurobiology, under lead researcher Dr. Mario Romero-Ortega, who is an associate professor at the department of bioengineering.
“TissueGen’s new technologies are redefining what is possible in how we approach nerve repair and regeneration,” said Dr. Romero-Ortega. “By providing the capability to deliver sensitive growth factors directly to the injury site, nerve regeneration can potentially be promoted without requiring tissue to be harvested from elsewhere in the patient’s body.”
Romero-Ortega and his team’s poster is titled “Computational modeling of drug release from nerve guide conduit.” The team sought to find a solution to the limitations of incorporating 3D chemotactic gradients in nerve repair scaffolds. ELUTE BDL fibers help create workable nerve guides that carry neutrophic agents wound in a coil. As a result, the researchers were able to demonstrate the guide’s ability to produce longer axons that had a more linear path, as compared to other nerve guides that carried linear neurotrophic agents.
The company is working on this method’s application in creating a medical device indicated for facilitating functional recovery of patients with spinal cord injuries. These nerve guides or scaffolds may be implanted surgically directly into a compromised spinal cord to stimulate regrowth of motor and sensory axons.
The annual Society for Neuroscience meeting, “Neuroscience 2014,” is scheduled to begin this weekend, November 15, and will run until Wednesday, November 19, 2014. The venue will be at the Walter E. Washington Convention Center in Washington, DC. Those interested to view the UT Dallas team’s presentation and learn more about TissueGen can visit the poster session on Sunday, November 16 from 1:00 p.m. to 5:00 p.m. in Hall A-C. Look for Poster No. 209.19/A44. Presentation will start at 3:00 p.m. For any questions, Dr. Nelson and his fellow researchers will be available throughout the conference. E-mail [email protected] to schedule a meeting.