Quite often, the development of novel therapies for one disease indication later gives rise to its application for other diseases as well. In the case of Multiple Sclerosis treatment, the non-profit Myelin Repair Foundation (MRF) may have identified a proven drug for hypertension that could be used to stimulate repair and protect the brain in MS patients.
The discovery will be further explored in a new clinical trial that will be facilitated through a Cooperative Research and Development Agreement (CRADA) between the MRF and the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) at the NIH Clinical Center, which will seek to assess the use of hypertension drug MRF-008 as a potential neuroprotective therapeutic for Multiple Sclerosis.
The collaboration between the MRF and NIH is a unique one, since the Myelin Repair Foundation is a true non-profit research group that directs its research goals from a completely practical, patient-driven perspective, seeking to develop tangible Multiple Sclerosis treatments that can be realistically developed and commercialized. The Foundation’s commitment to publishing provable, reproducible results, together with the vast talent and resources at the NIH, bode well for fully exploring the efficacy of MRF-008 patients.
Scott Johnson, CEO, President and Founder of the Myelin Repair Foundation and himself a Secondary Progressive MS patient seeking viable, effective treatments in the near future, commented on the Foundation’s new collaboration with the NIH and what it could mean to future MS treatment options, stating, “As a non-profit organization beholden to patients, not profits, we are uniquely positioned to advance MRF-008, a generic drug identified by the MRF academic consortium, forward as a novel therapeutic candidate to stimulate repair for multiple sclerosis,” adding that, “With the NIH’s eminent expertise in MS clinical trials, we have found an exemplary partner to conduct the research necessary to assess MRF-008. With world-class advisors, academic scientists, industry partners and this opportunity to collaborate with NIH scientists, we remain on track to develop and deliver the next generation of MS therapeutics for patients.”
The MRF delivers substantial results from its research through the Foundation’s Accelerated Research Collaboration™(ARC™) model, which is designed to accelerate promising therapeutics to market through streamlining the research and development of promising compounds from the lab to the clinic, and ultimately to Multiple Sclerosis patients. MRF leveraged its ARC model to forge its new relationship with the NIH on studying the viability of MRF-008, and will continue to utilize the platform to facilitate partnerships between top academic scientists, pharmaceutical partners, and other key biotech and life sciences influencers.
The Myelin Repair Foundation will work closely with the NIH to assess MRF-008 as a therapeutic candidate in an MS clinical trial. MRF-008 is a generic FDA-approved compound for the treatment of hypertension identified by the Myelin Repair Foundation’s academic research consortium as a novel drug repurposing candidate for neuroprotection to stimulate MS repair. Dr. Irene Cortese, M.D. and Dr. Daniel Reich, M.D., Ph.D. will lead the research study at the NIH.
Visit the Myelin Repair Foundation to learn more about MRF-008.