Dr. Akhilesh Gaharwar, an assistant professor at the Department of Biomedical Engineering at Texas A&M University, is lead editor of a new biomedical textbook entitled Nanomaterials in Tissue Engineering: Fabrication and Applications.
“The book,” Dr. Gaharwar says in a TAMU release, “is a standard reference for researchers and tissue engineers with an interest in nanomaterials, laboratories investigating biomaterials, and academics interested in materials science, chemical engineering, biomedical engineering and biological sciences. It explores the fabrication of a variety of nanomaterials and the use of these materials across a range of tissue engineering applications.”
As its title indicates, the book’s focus is on the fabrication of nanomaterials for tissue engineering applications and includes chapters on engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials. Dr. Gaharwar notes that it also highlights the application of nanomaterials in soft tissue engineering, and includes chapters on cardiac, neural and cartilage tissue engineering, and that that the use of nanomaterials in hard tissue engineering applications, including bone, dental and craniofacial tissue engineering, is also detailed.
Dr. Gaharwar, who joined Texas A&M this year, received his Ph.D. in biomedical engineering from Purdue University in 2011 and worked at the Massachusetts Institute of Technology and Harvard University as a postdoctoral associate. His research spans diverse fields, including materials science, chemistry, biology and microfabrication of polymeric biomaterials and nanocomposites.
Research at the Inspired Nanomaterials and Tissue Engineering (iNanoTE) Lab at TAMU, led by Dr. Gaharwar, spans diverse fields, including materials science, chemistry, stem cells biology and microfabrication of polymeric biomaterials and nanocomposites. Specifically, the lab is developing biomimetic nanomaterials with native interface tissue-like gradient in physical and chemical properties, integrating advanced micro- and nano- fabrication technologies to mimic native interface tissue architecture and directing stem cell behavior to obtain regionalized tissue constructs in vitro and in vivo. This integrated approach brings together a range of seemingly disparate disciplines that will address some of the complexity associated with engineering functional tissue interfaces in a manner that is otherwise not possible. The Gaharwar Lab’s research approach is focused on innovation and translational research in Biomedical Engineering, Materials Science and Stem Cells, its mission to create a research environment that stimulates and fosters a broad range of interdisciplinary approaches to understand nanomaterials-stem cell interactions, and to bridge the gap between scientific discovery and clinical translation. In particular, the lab’s objectives are to:
(a) Develop and support a highly collaborative research environment in the area of materials science, stem cell biology, and engineering;
(b) Focus on both fundamental and translational research in regenerative medicine; and
(c) Encourage rapid translation of discoveries into innovative and practical clinical applications.
“We aim to design ‘smart’ nanomaterials and customize microenvironmental cues to modulate stem cell behavior to address some of the complexity associated with engineering functional tissue” says Dr. Garwahar.
“Nanomaterials in Tissue Engineering: Fabrication and Applications is published by Woodhead Publishing Ltd. It is co-edited by Shilpa Sant of the University of Pittsburgh, Matthew Hancock of the Broad Institute and Adam Hacking of the Laboratory for Musculoskeletal Research and Innovation at Massachusetts General Hospital.
The publisher’s notes say that “Tissue engineering promises to revolutionize the way millions of patients with organ failure or tissue damage are treated. Yet the challenges are significant. Materials synthesis, characterization, design, and application are a central part of tissue engineering. This book provides guidance on these important issues, particularly at the nanoscale.”
After an introductory chapter, the book is divided into three parts: 1)The fabrication of nanomaterials for tissue engineering applications, 2)the application of nanomaterials in soft tissue engineering, and 3) the application of nanomaterials in hard tissue engineering. The six chapters in part one review novel techniques, such as layer-by-layer self-assembly, synthesis of carbon based systems, creation of nanofibrous scaffolds, and delivery of growth factors. The following section examines, in particular, vascularized tissue, heart neural tissue, and cartilage and ligaments. The concluding section considers bone, dental, and craniofacial tissues. Dr. Gaharwar’s book is available from various booksellers, including:
Barnes and Noble
Photos courtesy TAMU