The Texas Biomedical Research Institute (Texas Biomed), a leading independent biomedical research institution located in San Antonio, has found that a naturally occurring substance can help in the fight against melanoma, the primary cause of death from skin cancer.
Gossypin is the name of the compound and it is typically found in fruits and vegetables. It has been discovered to act as a natural inhibitor to two different genetic mutations, both of which are used in the prevention of skin cancer.
“Our results indicate that gossypin may have great therapeutic potential as a dual inhibitor of mutations called BRAFV600E kinase and CDK4, which occur in the vast majority of melanoma patients. They open a new avenue for the generation of a novel class of compounds for the treatment of melanoma,” said Hareesh Nair, Ph.D. Of Texas Biomed.
They have found that gossypin helps limit cell proliferation of melanoma and reduces the growth rate of tumors. They have further found that those that eat a diet rich in gossypin have a higher survival rate after contracting skin cancer than those that did not.
The study can be found in the March 29th Molecular Cancer Therapeutics and was supported by the Texas Biomedical Forum and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. The study showed that 10 days of gossypin treatment on human melanoma cell tumors with the transplanted into mice increased survival rate and reduced tumor volume.
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