The latest research conducted by researchers at the University of Texas Medical Branch at Galveston has led to some disturbing discoveries. The Texas researchers have identified the effect of multiple xenoestrogens in small doses that may lead to huge alterations in normal hormonal environment of the body..
Xenoestrogens are compounds that are obtained from the environment and, due to inherent estrogen properties (when administered in human body), these compounds can alter or significantly affect the balance of estrogen. Several researchers have already identified a number of potential xenoestrogens that may increase the risk of potential health issues like obesity, aberrations in normal estrogen levels of the body, defects in sperm viability, or motility and ovarian dysfunction.
The Texas based researchers prepared a mixture of 3 commonly occurring xenoestrogens — bisphenol S, bisphenol A (both are present in significant amounts in plastic bottles) and nonylphenol (present in industrial detergents) — and tested the effects on the tissue cultures of rat pituitary glands (that mimic human pituitary in physiological functioning). The aim of the experiment was to measure the clinical and cellular responses to estradiol alone and estradiol mixture with three xenoestrogens in small doses (bisphenol A, bisphenol S and nonylphenol).
The results led to the finding that each of these xenoestrogens have a far more lethal action on body tissues when administered in combination with other xenoestrogens leading to significant alterations in the secretion and metabolism of endocrine hormones especially estroge.
The results of this research are published in the renowned journal Environmental Health. The senior author of the study, UTMB professor Cheryl Watson expressed his views in these words:
“These compounds work at very low concentrations — at the parts per trillion or parts per quadrillion level — and when you mix them together they affect estrogenic signaling differently and more dramatically than they do individually,”
Maintenance of integrity of estrogen metabolism is of critical importance in both males and females, since estrogen governs normal metabolic activities, sexual function, reproductive functions, and immunological functioning of the body. Research data indicates that the urine of almost 90% of Americans contain varying concentration of bisphenol A and bisphenol S, which indicates a threat to the hormonal well-being of individuals. Watson suggests that the testing of these chemicals is very important in order to ascertain the toxic dosage and mechanism by which these alterations occur in the body. Further research is expected to expose the hazardous effects of more commercial xenoestrogens so that the products can be redesigned or substituted for the safety and health of individuals.