Endothelix, Inc. is a cardiovascular device company based in Houston, Texas and is focused on non-invasive vascular function measurement. The company originated from the Texas Medical Center-Houston from a collaborative project between the Texas Heart Institute and The University of Texas Health Science Center at Houston. Endothelix received a $1 million award from the Texas Emerging Technology Fund to develop the VENDYS® technology.
Endothelix’s first product is VENDYS, a non-invasive, inexpensive, and easy to use vascular function test. VENDYS is FDA cleared and is currently marketed throughout the United States, Europe and Canada. The company has a pipeline of innovative products.
What is VENDYS?
In simple terms, VENDYS® measures vascular reactivity.
VENDYS® uses a standard arm-cuff vascular reactivity procedure, which includes a temporary occlusion of blood flow in the arm. During the cuff occlusion, the lack of blood flow (ischemia) elicits a microvascular dilative response (opening small vessels). Upon releasing the cuff, blood flow rushes into the forearm and hand, not only restoring baseline flow but also resulting in an overshoot (reactive hyperemia). This overshoot causes shear stress in the larger (conduit) arteries, which stimulates these arteries (macrovessels) to dilate and accommodate the increased blood flow.
VENDYS® monitors, records, and analyzes fingertip temperature during the above cuff occlusion and release procedure. Temperature changes serve as a surrogate marker of blood flow changes that result from vascular reactivity.